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Department of Biomedical Engineering

Research

Healthercare & Medical devices Research > Healthercare & Medical devices

  • AB Lab.
  • CNA Lab.
  • mnE Lab.
  • NBT Lab.
  • SUH Lab.
  • BCAS Lab.
  • LAB2 Lab.

Applied Bioelectronics Laboratory (Professor Hyoungsuk. Yoo)

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AB Lab introduction : Welcome to the website of the Applied Bioelectronics Laboratory (ABLab) at Hanyang University, Seoul, South Korea. The lab has been established since 2011. Being a lab equipped with advanced research facilities and high-end computer technology, we have continued doing promising research in the field of RF coils, High-field MRIs, Antenna Systems, Implantable Medical systems, Electromagnetics, RF safety, Metamaterial, Wireless Power Transfer, Image Processing, etc. One part of our lab is equipped with various biomedical instruments, equipments, materials and chemicals for performing different experiments by using biological phantoms (head model, saline solution, ASTM phantom). The goals of ABLab are (i) Developing the MRI multi-channel RF coil system for UHF MRI and customized its design for better transmit efficiency. (ii) To develop the millimeter wave 60 GHz metamaterials for future high-speed 5G communications. (iii) The current focus of our lab is to design an efficient WPT system for near field communications and electrical vehicle charging. The WPT system overcome the problem of low power transfer efficiency, safety of IMDs antennas, and human safety with IMDs exposed to WPT system. The lab focusses also on Tattoo design and DBS for user safety. Also, we have collaborated with Georgia-Tech and developed the intraoral tongue drive system for user facilitation.

Fields and Topics Recent research results

MRI RF Coil Design / RF safety for IMD

  • Develop multi-channel coil for UHF MRI
  • Customized design for better transmit efficiency
  • Analyze thermal effect by metallic implant device
  • Develop method to alleviate heating
  • Integration of High-permittivity dielectric pad for transmission efficiency improvement.
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Millimeter waves 60 GHz metamaterials

  • Designing different types of metamaterials for 60 GHz high data rates communication.
  • High frequency VNA measurements.
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MRI RF safety of Tattoos

  • Different shape Tattoos design and fabrication.
  • Safety management for MR patient
  • Protection by PDMS and EBG
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Wireless charging systems

  • Design of highly efficient wireless power system
  • High efficiency rectifier design
  • To develop high efficiency energy harvesting system
  • Room-based WPT system
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WPT system design/ RF safety with IMDs

  • Wireless power transfer system design
  • WPT system for deep body implants
  • WPT system for high power applications (charging EVs and mobiles)
  • Safety of IMDs antenna
  • Human safety with IMDs exposed to WPT system
 Research Results-image4

Intraoral Tongue Drive System

  • Dual band iTDS transmitters design at 433 and 915 MHz
  • Safety of iTDS antenna in the mouth
  • Link budget analysis for wireless mouth to external unit communications
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WICP Device

  • Wireless ICP Device Design
  • RF transmitter and receiver design
  • WPT and data telemetry
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Implantable antenna system design

  • Implantable antenna system for deep body implants
  • Human safety
  • Application based designs and system integration
  • MTM integration for efficiency improvements
  • Link budget analysis for wireless communications
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Advance equipment’s in ABLab

  • Work stations (Dell precession tower 7810)
  • HFSS
  • Sim4Life
  • Etching Room
  • Light box UV exposure Mod#Az210
  • PhotoLami 3500 plus
  • Spectrum Analyzer Model: Anritsu MS2830A
  • RF amplifier Model: 15S1G6
  • ASTM phantom
  • Vector Network Analyzer (VNA) Model: MS46522A
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Computational NeuroImage Analysis Lab. (Professor Jong Min. Lee)

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Computational NeuroImage Analysis Lab. (CNA) has a goal of developing advanced neuroimage processing, analysis and interpretation, and the early detection of various neurodegenerative diseases based on the results. Main research areas cover the development of the advanced automated large scale 3-dimensional neuroimage processing and analysis algorithms, and single subject analysis system based on the large scale multimodal neuroimage database system. There are many active collaborators from the medical side including neurologists, psychiatrists and radiologists. From this kind of collaboration, we published more than 100 SCI papers and have tried to apply the developed algorithm to the real clinical cases. Also, we have collaborated with a couple of internally renowned lab such as MNI and NIH. We focused neuroimage analysis for the last 10 years and achieved two major grants NRL and NLRL. We also started to collaborate with Samsung Electronics in order to transfer our specialized knowledge to the medical products.

Aare & Major contents Major results (representative scientific papers)

Cortical parametric model development and applications

  • Development of an accurate cortical parametric model
  • Development of novel morphological parameters based on the model
  • Applications on the detection of the structural changes in the neurodegenerative diseases from the collaborations with the clinicians
  • Jun Ki Lee, Jong-Min Lee*, June Sic Kim, In Young Kim, Alan C. Evans, Sun I. Kim, A novel quantitative cross-validation of different cortical surface reconstruction algorithms using MRI phantom, Neuroimage, Vol. 31(2), p. 572-84, 2006 June
  • Kiho Im, Jong-Min Lee*, Oliver Lyttelton, Sun Hyung Kim, Alan C. Evans, Sun I. Kim, Brain Size and Cortical Structure in Adult Human Brain, Cerebral Cortex, Vol. 18(9), p. 2181~2191, 2008 September

Deep brain structure shape analysis and applications

  • Development of an advanced automatic segmentation of the deep brain structure
  • Development of an accurate parameter model
  • Development of an detection of the local changes based on the model
  • Applications on the detection of the structural changes in the neurodegenerative diseases from the collaborations with the clinicians
  • Sun Hyung Kim, Jong-Min Lee*, Hyun-Pil Kim, Dong Pyo Jang, Yong-Wook Shin, Tae Hyon Ha, Jae-Jin Kim, In Young Kim, Jun Soo Kwon, Sun I. Kim, Asymmetry Analysis of Deformable Hippocampal Model Using the Principal Component in Schizophrenia, Human Brain Mapping, Vol. 25(4), p. 361-369, 2005 August
  • Do-Hyung Kang, Sun Hyung Kim, Chi-Won Kim, Jung-Seok Choi, Joon Hwan Jang, Myung Hun Jung, Jong-Min Lee, Sun I. Kim, Jun Soo Kwon, Thalamus surface shape deformity in obsessive-compulsive disorder and schizophrenia, NeuroReport, Vol. 19(6), p. 609-613, 2008 April

Diffusion Tensor Imaging analysis and applications

  • Development of Diffusion Tensor Imaging analysis package (Samsung Electronics)
  • Development of the accurate analysis of the white matter combined with the structural image
  • Applications on the detection of the white matter changes in the neurodegenerative diseases from the collaborations with the clinicians
  • Bang-Bon Koo, Ning Hua, Chi-Hoon Choi, Itamar Ronen, Jong-Min Lee, Dae-Shik Kim, A Framework to Analyze Partial Volume Effect on Gray Matter Mean Diffusivity Measurements, Neuroimage, Vol. 44(1), p. 136~144, 2009 January
  • Jun-Sung Park, Uicheul Yoon, Ki-Chang Kwak, Sang Won Seo, Sun I. Kim, Duk L. Na and Jong-Min Lee*, The relationships microstructural properties of the midsagittal corpus callosum in human brain, NeuroImage, Vol. 56(1), p. 174-184, 2011 May

Functional MRI analysis and applications

  • Development of the analysis tool of the brain connectivity
  • Development of the automatic parcellation method based on the functional connectivity
  • Development of software for multimodal dynamic neuroimaging
  • Development of an accurate detection of the brain activities combined with the cortical parameter model
  • Applications on the detection of the brain connectivity changes in the neurodegenerative diseases from the collaborations with the clinicians
  • Hang Joon Jo, Jong-Min Lee*, Jae-Hun Kim, Chihoon Choi, Bon-Mi Gu, Do-Hyung Kang, Jeonghun Ku, Jun Soo Kwon, Sun I. Kim, Artificial shifting of fMRI activation localized by volume- and surface-based analyses, NeuroImage, Vol. 40(3), p. 1077-1089, 2008 April
  • Jae-Hun Kim, Jong-Min Lee*, Hang Joon Jo, Sook Hui Kim, Jung Hee Lee, Sung Tae Kim, San Won Seo, Robert W. Cox, Duk L. Na, Sun I. Kim, Ziad S. Saad, Defining functional SMA and pre-SMA subregions in human MFC using resting state fMRI: functional connectivity-based parcellation method, NeuroImage, Vol. 49(3), p. 2375-2386, 2010 February

Early detection of the neurodegenerative disease based on the neuroimage

  • Automatic classification of Normal control /MCI / Alzheimer Diseases
  • Single subject analysis based on the large scale database system
  • High classification performance between AD and the normal control (>95%)
  • In preparation of the acquiring the neuroimage data from more than 20 hospitals

micro.nano.Engineering Lab. (Professor Sungyoung. Choi)

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The micro.nano.Engineering Laboratory focuses on the development of innovative micro-nano-bio-engineering tools that can not only greatly advance our understanding of cell mechanics and biology, but also be easily commercialized and translated to widely-distributed commodities for cell-based therapeutics, point-of-care diagnostics, cell mechanics, and micro-/nano-technologies.

Specific research areas Recent results

Separation science and technology

  • White blood cell purification technology for blood sample preparation for immunophenotyping
  • Rapid enrichment of residual white blood cells for quality control of blood products
  • High-throughput nucleated cell removal for treatment for patients with acute leukemia
  • Stem cell separation based on cell rolling dynamics
 Research Results-image2
Cover articles for white blood cell separation (left) and stem cell separation (right) featured in Small and Lab on a Chip.

Open-source bioengineering tools

  • Optofluidic modular blocks as an open-source development tool for bioengineering
  • Open-source digital droplet PCR for open-access molecular diagnostics
  • Open-source spectrometer for field-portable biochemical assays
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Cover article for optofluidic modular blocks featured in Small (left) and a representative module assembly for blood agglutination assay (right).

microFlow Cytometry

  • Residual white blood cell counter based on white blood cell enrichment
  • Sheathless, pumpless microflow cytometry based on a constant flow-rate source
  • Digital flow cytometry for multiplexed analysis of immune cells
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Schematic of a microflow cytometry for blood analysis (left) and a representative microflow cytometry for residual white blood cell counting (right).

Point-of-care Diagnostics

  • Blood sample preparation technologies for point-of-care molecular diagnostics
  • DNA biosensors for sensitive detection of biomarkers in blood
  • Immunological technologies for isolation and analysis of blood exosomes for liquid biopsy
Research Results-image4
Cover article shwoing a blood plasma separation platform for field-portable blood

NanoBio Technology Lab (Professor Sun Jeong. Kim)

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Aging decreases physical functions of human body which causes presbyopia, muscle regression and so on. Bio-artificial muscle system could replace or complem-ent naturally regressed or damaged muscles, and can be applied to robots, and bio-industry which contribute greatly to developments in science and industry. Recently, an investigation into chemomechanical system as an artificial muscle has been carried out. The materials used in the chemomechanical system converted chemical free energy into mechanical energy in response to an external stimulus, such as pH, light, or electrical and magnetic fields, and showed an actuation behavior through this energy conversion. Because the actuation behavior of such materials needs to be controlled rapidly and exactly to apply to the living body, an electric stimulus has potential use as an artificial muscle. Points that need to be overcome in bio-artificial muscle system research aimed at natural muscle are: improvements in efficiency, increasing mechanical power; a prompt response; low energy consumption; and biocompatibility. It is also important for bio-artificial muscle system to be able to interface with neural tissue and muscle in the living body. The goals of NBT lab are (i) Developing bio-artificial muscles that have biocompatibility to be able to interface with tissues and have functions that can be driven by a low-power source supply, and that have stress and strain characteristics similar to those of natural muscle. (ii) To develop bio-artificial muscle system that is controllable using bio-signals (electrical and chemical signals) from nerve tissue and muscle, driven by a nano-biofuel cell.

Fields & Topics Recent research results

High-speed rotational Artificial muscle

  • Creativity: Biomimetic carbon nanotube-based artificial muscles using a twist of giving an excellent rotational performance.
  • Research Value: Micro motors, robots and industrial fluids, Lab-on-a-chip, drug delivery, medical industry with future-oriented research, presents a new paradigm to artificial muscles research.
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Graphene / carbon nanotube hybrid composite research

  • Creativi - Creativity: Array of self-aligned nanomaterials to increase mechanical toughnessbsp; Identified the phenomenon of self-aligned graphene and carbon nanotube array
  • Using graphene and carbon nanotubes as mimicking nanostructured spider webs.
  • Research Value: Bulletproof vests, automobile reinforcements, electronics industry, lightweight and high strength composite materials for industrial applications.
 Research Results-image2

Porous artificial tissue with DNAs to make Artificial Muscles

  • Creativity: Controlling porosity and mechanical properties of artificial muscle by Calcium and ionic liquid.
  • Research value: Biocompatible Energy storage material, electrochemical sensors and cell cultures.
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High elasticity having carbon nanotubes composites artificial muscles

  • Creativity: An accordion-shaped nanocomposite structure which shows reversible elastic and conductive property.
  • Research value: Contribute to bioelectrode materials and energy devices which needs flexibility and elasticity.
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Smart Ubiquitous Healthcare Lab. (Professor In Young. Kim)

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Ubiquitous Healthcare

Ubiquitous healthcare (U-healthcare) is the medical service for checking individual health status at anywhere and anytime using wireless telecommunication technique, so it is getting the spotlight as major part of future industry. The system of ubiquitous healthcare can acquire user’s bio-signal during free life without any limits of activity (Non-intrusive), and it gives user the information of individual health status or medical opinion that is based on continuously or periodically acquired data. In addition, when an emergency situation occurs, it will be possible to service quick medical treatment by knowing family or physician. The various U-healthcare researches are currently processing about non-intrusive and non-invasive bio-signal monitoring in Smart Ubiquitous Healthcare Lab at Hanyang University. Mainly, researches that are linked with cardiovascular system have progressed, and most of projects have focused on blood pressure, electrocardiography, physical activity, data mining, and physiological modeling.

Hearing Science

We have been studying in a variety of fields to improve the performance of the digital hearing aids that recover some hearing impaired people. Specifically, our researches focus on the digital signal processing to improve the speech enhancement. We are researching digital hearing aids with high-quality sound and are developing algorithms and designs for signal processing. Digital hearing aids provide dramatic sound enhancement, improved communication ability and unequalled flexibility to match individual user needs. We are studying the techniques (companding, wide dynamic range compression etc.) which are generally related in the digital hearing aids. Also, we are interested in training induced auditory rehabilitation. Current research theme is auditory sensitivity enhancement by auditory sound training.

Neural Engineering

arly exploration of neural systems focused on understanding how neural systems work at the cellular, tissue, and system levels, and engineering methodologies were developed to detect, process, and model these neural signals. Recently, tremendous progress has been made in the field of neural engineering, not only understanding the mechanism, detection, and processing of the neural signals, but also on restoring the impaired neural systems functions and interfacing the neural systems with artificial devices and machines.

Fields & Contents Results

Ubiquitous Healthcare

  • Blood Pressure Measurement & Applications
  • Sports Medicine & Physiology
  • Data Mining
  • Modeling and Simulation for Human Organs and Cardiovascular System
 Research Results-image1

Hearing Science

  • Hearing aid research
  • Hearing psychophysics research
 Research Results-image2

Neural Engineering

  • Rewiring the Brain
  • Develop Next-generation Deep Brain Stimulator
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Biomedical Circuit and System Lab. (BCAS Lab.)

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The Biomedical Circuits and Systems Laboratory (BCAS) is a place that conducts research on circuit design and overall systems that can be used in various electronic medicines, medical devices, and wearable devices that are used throughout the biomedical field such as biomedical devices and healthcare. Due to the increase in demand for high-quality medical services and medical devices following an aging population and an increase in life expectancy, the electronic medicine market, including biomedical devices, has recently received the most heated attention among medical devices, and cooperation in convergence technologies of various technologies is essential. Among many biomedical-related technologies, this laboratory focuses on circuit design, wireless power transmission, and wireless data transmission related technologies, and seeks to create new values ​​through the convergence of these technologies. The various hardware-based research pursued by this laboratory can be applied to the entire biomedical field, and has the advantage of being widely used in mobile and IoT devices.

Research Results-image1
Fields and Topics Recent research results

Miniaturized implant system for central/peripheral nervous system

 "An inductively-powered wireless neural recording and stimulation system for freely-behaving animals," IEEE Trans. Biomed. Circuits Syst, vol. 13, no. 2, pp. 413-424, April 2019.

Low-power integrated circuit (IC) design for biomedical/healthcare system

 "A 80x60 Micro-Bolometer CMOS Thermal Imager Integrated with a Low-Noise 12-Bit DAC," IEEE Trans. Industrial Electronics, vol. 69, no. 8, pp. 8604-8608, Aug. 2022

High efficiency wireless power transfer system for biomedical/healthcare/IoT system

 "Full-Duplex Enabled Wireless Power Transfer System via Textile for Miniaturized IMD," Biomedical Engineering Letters, vol. 12, pp. 295-302, July 2022.

Laboratory for Advanced Biomaterials & Biodevices (LAB2 Lab.)

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Our research goal is to break down the boundaries between physics and biology. Nanoscale properties of biological materials become more and more important to understanding and controlling biological phenomena. We believe that our expertise, and studies for the interaction of quanta and biological materials on the nanoscale, provide useful and unprecedented ways to understand the nano-bio interface.

Research Results-image1
Fields and Topics Recent research results

Biomedical Electronics Using Biomaterials

 "Multifunctional and ultrathin electronic tattoos for on-skin diagnostic and therapeutic applications," Adv. Mater. 33, 2008308, 2021.

Bioinspired Optics

 "Deformable and conformal silk hydrogel inverse opal," PNAS, 114, 6185, 2017.

Lithography and Nanofabrication on Biomaterials

 "Engineering silk protein to modulate polymorphic transitions for green lithography resists," ACS Appl. Mater. & Interfaces, 14, 56623, 2022.